Multi-faceted maropitant
This is all a bit of a revelation: we know maropitant is an effective anti-emetic but….
It’d be great to have a potential new analgesic wouldn’t it?
PLoS One. 2015 Oct 29;10(10):e0140734. doi: 10.1371/journal.pone.0140734. eCollection 2015.
Comparison of NK-1 Receptor Antagonist (Maropitant) to Morphine as a Pre-Anaesthetic Agent for Canine Ovariohysterectomy.
Marquez M1, Boscan P1, Weir H1, Vogel P1, Twedt DC1.
https://www.ncbi.nlm.nih.gov/pubmed/26513745
Handy if it was anti-inflammatory too:
J Vet Med Sci. 2018 Mar 24;80(3):492-498. doi: 10.1292/jvms.17-0483. Epub 2018 Jan 16.
The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis.
Tsukamoto A1, Ohgoda M1, Haruki N1, Hori M2, Inomata T1.
https://www.ncbi.nlm.nih.gov/pubmed/29343664
And while we’re at it, a new anti-tussive would be jolly useful since it seems that diphenoxylate and butorphanol tablets are both still unavailable:
J Vet Intern Med. 2016 May;30(3):847-52. doi: 10.1111/jvim.13935. Epub 2016 Mar 20.
Investigation of Neurokinin-1 Receptor Antagonism as a Novel Treatment for Chronic Bronchitis in Dogs.
Grobman M1, Reinero C
https://www.ncbi.nlm.nih.gov/pubmed/26995558
We’re just starting to explore the potential of this lot. Our initial impression is that Cerenia tablets are indeed useful in managing cough due to bronchomalacia or tracheal collapse for example.
To update this post: the following article suggests yet further applications in dermatology.
